| 1 | Approve scheme of arrangement and related matters | For |
| 2 | Approve Part A of Shire Pharmaceuticals Group plc Portfolio Share Plan | Oppose |
| 3 | Approve Part B of Shire Pharmaceuticals Group plc Portfolio Share Plan | Oppose |
| 4 | Approve the adoption by Shire plc of the Shire plc Sharesave Scheme and approve authorisation given to directors of Shire plc in relation hereto. | For |
| 5 | Approve adoption by Shire plc of Shire plc Portfolio Share Plan (Part A) | Oppose |
| 6 | Approve adoption by Shire plc of Shire plc Portfolio Share Plan (Part B) | Oppose |
| 7 | Approve adoption by Shire plc of Shire Pharmaceuticals Group plc Employee Stock Purchase Plan | For |
