

| SHIRE PLC | 24/09/2008 AGM | |
|---|---|---|
| 1 | Elect Matthew Emmens | Oppose |
| 2 | Elect Angus Russell | For |
| 3 | Elect Graham Hetherington | For |
| 4 | Elect Barry Price | For |
| 5 | Elect David Kappler | For |
| 6 | Elect Dr Jeffrey Leiden | For |
| 7 | Elect Patrick Langlois | For |
| 8 | Elect Kate Nealon | For |
| 9 | Elect David Mott | Abstain |
| 10 | Elect Dr Michael Rosenblatt | For |
| 11 | Appoint the auditors | Abstain |
| 12 | Allow the board to determine the auditors remuneration | For |
| 13 | Issue shares with pre-emption rights | For |
| 14 | Issue shares for cash | For |
| 15 | Authorise Share Repurchase | For |
| 16 | Approve the Name Change | For |