

| VERTEX PHARMACEUTICALS INCORPORATED | 17/05/2023 AGM | |
|---|---|---|
| 1.01 | Elect Sangeeta N. Bhatia | For |
| 1.02 | Elect Lloyd Carney | For |
| 1.03 | Elect Alan Garber | For |
| 1.04 | Elect Terrence C. Kearney | Oppose |
| 1.05 | Elect Reshma Kewalramani | For |
| 1.06 | Elect Jeffrey M. Leiden | Oppose |
| 1.07 | Elect Diana McKenzie | For |
| 1.08 | Elect Bruce I. Sachs | Oppose |
| 1.09 | Elect Suketu Upadhyay | For |
| 2 | Appoint EY as Auditors | Oppose |
| 3 | Advisory Vote on Executive Compensation | Oppose |
| 4 | Approve the Frequency of Future Advisory Votes on Executive Compensation | 1 |