

| VERTEX PHARMACEUTICALS INCORPORATED | 17/05/2018 AGM | |
|---|---|---|
| 1.1 | Elect Director Sangeeta N. Bhatia | For |
| 1.2 | Elect Director Jeffrey M. Leiden | Oppose |
| 1.3 | Elect Director Bruce I. Sachs | For |
| 2 | Board Proposal to eliminate Supermajority Voting | For |
| 3 | Amend Existing Long Term Incentive Plan | Oppose |
| 4 | Ratify Ernst & Young LLP as Auditors | Oppose |
| 5 | Advisory Vote to Ratify Named Executive Officers' Compensation | Oppose |
| 6 | Shareholder Resolution: Report on Drug Pricing Increases | For |
| 7 | Shareholder Resolution: Political Donations | For |