

| VERTEX PHARMACEUTICALS INCORPORATED | 08/06/2017 AGM | |
|---|---|---|
| 1.01 | Elect Alan Garber | For |
| 1.02 | Elect Margaret G. McGlynn | For |
| 1.03 | Elect William D. Young | For |
| 2 | Board Proposal to Declassify the Board | For |
| 3 | Amend the 2013 Stock and Option Plan | Oppose |
| 4 | Appoint the Auditors | Oppose |
| 5 | Advisory Vote on Executive Compensation | Oppose |
| 6 | Approve the Frequency of Future Advisory Votes on Executive Compensation | 1 |
| 7 | Shareholder Resolution: Simple Majority Voting | For |
| 8 | Shareholder Resolution: Political Donations | For |