

| VERTEX PHARMACEUTICALS INCORPORATED | 04/06/2015 AGM | |
|---|---|---|
| 1.01 | Elect Jeffrey M. Leiden | Withhold |
| 1.02 | Elect Bruce I. Sachs | Withhold |
| 1.03 | Elect Sangeeta N. Bhatia | For |
| 2 | Amend Articles: Increase number of shares authorised for issuance | Oppose |
| 3 | Amend 2013 Stock and Option Plan | Oppose |
| 4 | Ratify the appointment of the auditors | Oppose |
| 5 | Advisory vote on executive compensation | Oppose |
| 6 | Shareholder Resolution: Proxy access | For |
| 7 | Shareholder Resolution: Report on specialty drug prices | Abstain |