

| IONIS PHARMACEUTICALS INC. | 04/06/2020 AGM | |
|---|---|---|
| 1.1 | Elect Director Joseph H. Wender | Withhold |
| 1.2 | Elect Director B. Lynne Parshall | For |
| 1.3 | Elect Director Spencer R. Berthelsen | Withhold |
| 1.4 | Elect Director Joan Hernan | For |
| 2 | Amend Existing Omnibus Plan | Oppose |
| 3 | Porposal to ratyfy amending existing stock option and restricted stock unit awards of directors to adjust vesting. | For |
| 4 | Advisory Vote on Executive Compensation | Oppose |
| 5 | Appoint the Auditors | Oppose |