

| IONIS PHARMACEUTICALS INC. | 24/05/2017 AGM | |
|---|---|---|
| 1.01 | Elect Spencer R. Berthelsen | Withhold |
| 1.02 | Elect B. Lynne Parshall | Withhold |
| 1.03 | Elect Joseph H. Wender | Withhold |
| 2 | Amend the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan | Oppose |
| 3 | Advisory Vote on Executive Compensation | Oppose |
| 4 | Approve the Frequency of Future Advisory Votes on Executive Compensation | 1 |
| 5 | Appoint the Auditors | Oppose |