

| IONIS PHARMACEUTICALS INC. | 06/06/2019 AGM | |
|---|---|---|
| 1.1 | Elect Stanley T. Crooke | Withhold |
| 1.2 | Elect Joseph Klein, III | Withhold |
| 1.3 | Elect Joseph Loscalzo | For |
| 1.4 | Elect Michael Hayden | For |
| 2 | Elect Peter N. Reikes | For |
| 3 | Elect Brett Monia | Oppose |
| 4 | Amend Existing Omnibus Plan | Oppose |
| 5 | Advisory Vote on Executive Compensation | Abstain |
| 6 | Appoint the Auditors | Oppose |